Integrative Molecular Phenotyping
INTEGRATIVE MOLECULAR
PHENOTYPING
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY
DEPARTMENT OF MEDICAL
BIOCHEMISTRY AND BIOPHYSICS
WHEELOCK LABORATORY

PubMed

The Critical Role of Galectin-12 in Modulating Lipid Metabolism in Sebaceous Glands

Mon, 19/12/2022 - 12:00
J Invest Dermatol. 2022 Dec 16:S0022-202X(22)02842-1. doi: 10.1016/j.jid.2022.11.012. Online ahead of print.NO ABSTRACTPMID:36535362 | DOI:10.1016/j.jid.2022.11.012

Structural characterization and immunomodulatory activity of an exopolysaccharide from marine-derived Aspergillus versicolor SCAU141

Mon, 19/12/2022 - 12:00
Int J Biol Macromol. 2022 Dec 16:S0141-8130(22)03029-X. doi: 10.1016/j.ijbiomac.2022.12.127. Online ahead of print.NO ABSTRACTPMID:36535356 | DOI:10.1016/j.ijbiomac.2022.12.127

Lian-Qu formula treats metabolic syndrome via reducing fat synthesis, insulin resistance and inflammation

Mon, 19/12/2022 - 12:00
J Ethnopharmacol. 2022 Dec 16:116060. doi: 10.1016/j.jep.2022.116060. Online ahead of print.NO ABSTRACTPMID:36535333 | DOI:10.1016/j.jep.2022.116060

Thymol ameliorates ethanol-induced hepatotoxicity via regulating metabolism and autophagy

Mon, 19/12/2022 - 12:00
Chem Biol Interact. 2022 Dec 16:110308. doi: 10.1016/j.cbi.2022.110308. Online ahead of print.NO ABSTRACTPMID:36535314 | DOI:10.1016/j.cbi.2022.110308

Loss of glyoxalase 2 alters the glucose metabolism in zebrafish

Mon, 19/12/2022 - 12:00
Redox Biol. 2022 Dec 14;59:102576. doi: 10.1016/j.redox.2022.102576. Online ahead of print.NO ABSTRACTPMID:36535130 | DOI:10.1016/j.redox.2022.102576

Metabolomics and Genomics Enable the Discovery of a New Class of Nonribosomal Peptidic Metallophores from a Marine <em>Micromonospora</em>

Mon, 19/12/2022 - 12:00
J Am Chem Soc. 2022 Dec 19. doi: 10.1021/jacs.2c06410. Online ahead of print.NO ABSTRACTPMID:36535031 | DOI:10.1021/jacs.2c06410

Endothelial PTP4A1 mitigates vascular inflammation via USF1/A20 axis-mediated NF-κB inactivation

Mon, 19/12/2022 - 12:00
Cardiovasc Res. 2022 Dec 19:cvac193. doi: 10.1093/cvr/cvac193. Online ahead of print.NO ABSTRACTPMID:36534975 | DOI:10.1093/cvr/cvac193

Discovery of Aryloxy-, Arylthio-, and Arylamino-Containing Acethydrazides as Fungicidal Agents

Mon, 19/12/2022 - 12:00
J Agric Food Chem. 2022 Dec 19. doi: 10.1021/acs.jafc.2c06691. Online ahead of print.NO ABSTRACTPMID:36534960 | DOI:10.1021/acs.jafc.2c06691

Molecular Clusters and Tumor-Immune Drivers of IgM Monoclonal Gammopathies

Mon, 19/12/2022 - 12:00
Clin Cancer Res. 2022 Dec 19:CCR-22-2215. doi: 10.1158/1078-0432.CCR-22-2215. Online ahead of print.NO ABSTRACTPMID:36534518 | DOI:10.1158/1078-0432.CCR-22-2215

Human centenarian-associated SIRT6 mutants modulate hepatocyte metabolism and collagen deposition in multilineage hepatic 3D spheroids

Mon, 19/12/2022 - 12:00
Geroscience. 2022 Dec 19. doi: 10.1007/s11357-022-00713-1. Online ahead of print.NO ABSTRACTPMID:36534275 | DOI:10.1007/s11357-022-00713-1

The effects of extracellular algicidal compounds of Bacillus sp. B1 on Heterosigma akashiwo: a metabolomics approach

Mon, 19/12/2022 - 12:00
Environ Sci Pollut Res Int. 2022 Dec 19. doi: 10.1007/s11356-022-24255-3. Online ahead of print.NO ABSTRACTPMID:36534259 | DOI:10.1007/s11356-022-24255-3

Dysregulation of Amino Acid, Lipid, and Acylpyruvate Metabolism in Idiopathic Intracranial Hypertension: A Non-targeted Case Control and Longitudinal Metabolomic Study

Mon, 19/12/2022 - 12:00
J Proteome Res. 2022 Dec 19. doi: 10.1021/acs.jproteome.2c00449. Online ahead of print.NO ABSTRACTPMID:36534069 | DOI:10.1021/acs.jproteome.2c00449

Microbiome-Metabolomics Analysis of the Impacts of <em>Cryptosporidium muris</em> Infection in BALB/C Mice

Mon, 19/12/2022 - 12:00
Microbiol Spectr. 2022 Dec 19:e0217522. doi: 10.1128/spectrum.02175-22. Online ahead of print.NO ABSTRACTPMID:36533947 | DOI:10.1128/spectrum.02175-22

Untargeted Metabolomics-Assisted Comparative Cytochrome P450-dependent Metabolism of Fenbendazole in Human and Dog Liver Microsomes

Mon, 19/12/2022 - 12:00
Xenobiotica. 2022 Dec 19:1-26. doi: 10.1080/00498254.2022.2160676. Online ahead of print.NO ABSTRACTPMID:36533905 | DOI:10.1080/00498254.2022.2160676

2-hydroxyisobutyric acid (2-HIBA) modulates ageing and fat deposition in <em>Caenorhabditis elegans</em>

Mon, 19/12/2022 - 12:00
Front Mol Biosci. 2022 Nov 23;9:986022. doi: 10.3389/fmolb.2022.986022. eCollection 2022.NO ABSTRACTPMID:36533081 | PMC:PMC9749906 | DOI:10.3389/fmolb.2022.986022

Intestinal flora induces depression by mediating the dysregulation of cerebral cortex gene expression and regulating the metabolism of stroke patients

Mon, 19/12/2022 - 12:00
Front Mol Biosci. 2022 Nov 30;9:865788. doi: 10.3389/fmolb.2022.865788. eCollection 2022.NO ABSTRACTPMID:36533076 | PMC:PMC9748625 | DOI:10.3389/fmolb.2022.865788

Analyzing the Therapeutic Mechanism of Mongolian Medicine <em>Zhonglun</em>-5 in Rheumatoid Arthritis Using a Bagging Algorithm with Serum Metabonomics

Mon, 19/12/2022 - 12:00
Evid Based Complement Alternat Med. 2022 Dec 7;2022:5997562. doi: 10.1155/2022/5997562. eCollection 2022.NO ABSTRACTPMID:36532854 | PMC:PMC9750765 | DOI:10.1155/2022/5997562

Potential mechanisms of Lian-Zhi-Fan solution for TNBS-induced ulcerative colitis in rats <em>via</em> a metabolomics approach

Mon, 19/12/2022 - 12:00
Front Pharmacol. 2022 Dec 2;13:1014117. doi: 10.3389/fphar.2022.1014117. eCollection 2022.NO ABSTRACTPMID:36532763 | PMC:PMC9755326 | DOI:10.3389/fphar.2022.1014117

Combined metabolomics and network pharmacology to elucidate the mechanisms of Dracorhodin Perchlorate in treating diabetic foot ulcer rats

Mon, 19/12/2022 - 12:00
Front Pharmacol. 2022 Nov 18;13:1038656. doi: 10.3389/fphar.2022.1038656. eCollection 2022.NO ABSTRACTPMID:36532755 | PMC:PMC9752146 | DOI:10.3389/fphar.2022.1038656

Integration of transcriptomics and metabolomics reveals the molecular mechanisms underlying the effect of nafamostat mesylate on rhabdomyolysis-induced acute kidney injury

Mon, 19/12/2022 - 12:00
Front Pharmacol. 2022 Nov 29;13:931670. doi: 10.3389/fphar.2022.931670. eCollection 2022.NO ABSTRACTPMID:36532745 | PMC:PMC9748812 | DOI:10.3389/fphar.2022.931670

Pages